![\"\"](\"http:\/\/hdygyy.com.cn\/wp-content\/uploads\/2020\/10\/640-3-1.png\")
<\/p>\nA 73-year-old female of Asian origin was diagnosed with ulcerative colitis (UC) after initial gastrointestinal symptoms of abdominal pain and bloody diarrhea. She had a relatively benign course over the subsequent 12 years. In 2009, she had increased left-sided abdominal pain, bloody diarrhea and progressive weight loss, due to a severe exacerbation. In spite of a variety of standard treatments, her condition continued to decline with a significant impact on normal life and functioning. In December of 2010, repeat colonoscopy and microscopy confirmed pancolitis, without diverticulitis. The Specific Carbohydrate Diet (SCD) was initiated due to failure of conventional therapies. Following this highly restricted diet, within a period of 3\u20136 months, improvement was noted, and within a year, no abdominal pain or diarrhea were present, and she returned to her baseline functioning and career. Two years later, repeat colonoscopy showed resolution of the pancolitis, confirmed with microscopic evaluation. Successful use of the SCD in children with UC has been documented. We describe previously unreported, highly beneficial results with both symptomatic and clinical improvement and complete remission of UC in an adult female with the SCD.<\/p>\n
Key Words:\u00a0Ulcerative colitis, Inflammatory bowel disease, Dietary therapy<\/p>\n
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\u7279\u6b8a\u78b3\u6c34\u5316\u5408\u7269\u996e\u98df\uff08SCD\uff09\u7531Sidney Haas\u535a\u58eb\u548cElaine Gottschall\u63d0\u51fa\u3002SCD\u57fa\u4e8e\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u8425\u517b\u4e0d\u826f\u4e0eIBD\u76f8\u5173\u7684\u7406\u8bba\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u6539\u53d8\u996e\u98df\uff0c\u80a0\u9053\u83cc\u7fa4\u6709\u53ef\u80fd\u88ab\u6539\u53d8\uff0c\u4ece\u800c\u5bfc\u81f4\u6539\u5584\u3002\u996e\u98df\u5177\u6709\u53cc\u91cd\u4f5c\u7528\uff0c\u4e0d\u4ec5\u6d88\u9664\u4e86\u53ef\u80fd\u5bfc\u81f4\u8425\u517b\u4e0d\u826f\u7684\u56e0\u7d20\uff0c\u800c\u4e14\u8fd8\u5305\u62ec\u6062\u590d\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u7684\u529f\u80fd\u3002<\/p>\n
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<\/p>\n
A 73-year-old female of Asian origin with a long-standing history of UC presented with the most severe and persistent flare of her disease. She had received the initial diagnosis of UC in 1997 when she developed abdominal pain and rectal bleeding with loose mucous stools and underwent a diagnostic colonoscopy with a gastroenterologist. She responded to mesalamine (Asacol) given for a period of 6 weeks, which was later discontinued by the patient.<\/p>\n
For the next 12 years, she was relatively stable with standard American diet recommendations and did not exclude wheat and dairy or focused on the inclusion of particular fermented foods. The patient incorporated powdered ayurvedic and homeopathic oral treatment, which included some spices like nutmeg but did not contain any fresh or fermented products. In the winter of 2009, she experienced intermittent burning and shooting pain predominately in the left lower quadrant of the abdomen. Pain in the right lower quadrant was present often concomitantly, and on occasion, was present in the absence of the left-sided pain. Episodes of rectal bleeding and mucoid loose stools progressed over the duration of the next year. No fever or skin rashes were present at any time. Decreased appetite and overall weight loss of 7 pounds occurred within the 12 months. She was admitted at<\/p>\n
assorted facilities and underwent consultations with various gastroenterologists and other specialists, with increasing fatigue and finally, an inability to continue working.<\/p>\n
The differential diagnosis included diverticulitis and tuberculosis among others, all of which were excluded. Multiple, episodic and varied therapies including corticosteroids and mesalamine were prescribed, with limited efficacy and poor tolerance. In December of 2010, her weight was 128 pounds, and she appeared pale, fatigued and chronically ill. She had not been able to function as a physician and was in constant abdominal pain with unremitting bloody diarrhea. Hemoglobin of 10.5 g\/dl and mild hypokalemia of 3.2 mEq\/l was seen with no elevation of the liver enzymes and normal renal function. White blood cell count was normal. Colonoscopy was performed and revealed pancolitis (fig.\u00a0(fig.1)1) with sigmoid colonic diverticula but no evidence of diverticulitis or neoplastic changes. Mild to moderate IBD consistent with chronic UC was noted with patchy areas through the cecum, ascending, transverse, descending, and sigmoid and rectum, and some difficulty entering the ileocecal valve. The colonic mucosa revealed friability, multiple tiny ulcers and mucosal edema. Biopsies were obtained throughout the colon and confirmed UC.<\/p>\n
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\u9274\u522b\u8bca\u65ad\u5305\u62ec\u61a9\u5ba4\u708e\u548c\u7ed3\u6838\u75c5\u7b49\uff0c\u6240\u6709\u8fd9\u4e9b\u5747\u6392\u9664\u5728\u5916\u3002\u5904\u65b9\u4e86\u5305\u62ec\u76ae\u8d28\u7c7b\u56fa\u9187\u548c\u7f8e\u6c99\u5728\u5185\u7684\u591a\u79cd\u836f\u7269\uff0c\u591a\u79cd\u7597\u6cd5\uff0c\u7597\u6548\u6709\u9650\u4e14\u8010\u53d7\u6027\u5dee\u30022010\u5e7412\u6708\uff0c\u5979\u7684\u4f53\u91cd\u4e3a128\u78c5\uff0c\u663e\u5f97\u82cd\u767d\uff0c\u75b2\u5026\u4e14\u60a3\u6709\u6162\u6027\u75be\u75c5\u3002\u5979\u65e0\u6cd5\u80dc\u4efb\u533b\u751f\u7684\u5de5\u4f5c\uff0c\u5e76\u4e14\u6301\u7eed\u8179\u75db\uff0c\u4f34\u6709\u4e0d\u505c\u7684\u8840\u6027\u8179\u6cfb\u3002\u89c2\u5bdf\u5230\u8840\u7ea2\u86cb\u767d\u4e3a10.5 g \/ dl\uff0c\u8f7b\u5ea6\u4f4e\u94be\u8840\u75c7\u4e3a3.2 mEq \/ l\uff0c\u809d\u9176\u672a\u5347\u9ad8\uff0c\u80be\u529f\u80fd\u6b63\u5e38\u3002\u767d\u7ec6\u80de\u8ba1\u6570\u6b63\u5e38\u3002\u8fdb\u884c\u7ed3\u80a0\u955c\u68c0\u67e5\u5e76\u53d1\u73b0\u9ecf\u819c\u708e\uff08\u56fe\u3002\uff08\u56fe\u30021\uff091\u4e2a\u4e59\u72b6\u7ed3\u80a0\u61a9\u5ba4\uff0c\u4f46\u65e0\u61a9\u5ba4\u708e\u6216\u8d58\u751f\u7269\u6539\u53d8\u7684\u8bc1\u636e\u3002\u8f7b\u5ea6\u81f3\u4e2d\u5ea6IBD\u4e0e\u6162\u6027UC\u76f8\u7b26\uff0c\u76f2\u80a0\uff0c\u4e0a\u5347\uff0c\u6a2a\u5411\uff0c\u4e0b\u964d\uff0c\u4e59\u72b6\u7ed3\u80a0\u548c\u76f4\u80a0\u6709\u6591\u7247\u533a\u57df\uff0c\u8fdb\u5165\u56de\u76f2\u80a0\u74e3\u819c\u6709\u4e9b\u56f0\u96be\u3002\u7ed3\u80a0\u7c98\u819c\u663e\u793a\u6613\u788e\uff0c\u591a\u5904\u5c0f\u6e83\u75a1\u548c\u7c98\u819c\u6c34\u80bf\u3002\u6574\u4e2a\u7ed3\u80a0\u5747\u83b7\u5f97\u6d3b\u68c0\u5e76\u8bc1\u5b9e\u4e3aUC<\/p>\n
<\/p>\n
\u56de\u80a0\u672b\u7aef\uff08a<\/strong>\uff0cb<\/strong>\uff09\u548c\u76f2\u80a0\uff08c<\/strong>\uff09\u3002\u4e59\u72b6\u7ed3\u80a0\u548c\u5de6\u4fa7\u7ed3\u80a0\u7684\u5185\u7aa5\u955c\u7167\u7247\u8868\u660e\uff0c\u572873\u5c81\u7684\u60a3\u8005UC\u6025\u6027\u52a0\u91cd1\u5e74\u540e\uff0c\u4e8e2010\u5e7412\u6708\u5b9e\u65bdSCD\u4e4b\u524d\u62cd\u6444\u4e86\u6d3b\u52a8\u6027\u7c98\u819c\u708e\u75c7\u3002\u5728\u5b8c\u5168\u7ed3\u80a0\u955c\u68c0\u67e5\u4e2d\u53d1\u73b0\u9ecf\u819c\u708e\u3002<\/p>\n \u7531\u4e8e\u60a3\u8005\u5177\u6709\u6301\u7eed\u6027\u548c\u8fdb\u884c\u6027\u75c7\u72b6\uff0c\u5e76\u4e14\u4e34\u5e8a\u53c2\u6570\u4e0d\u65ad\u6076\u5316\uff0c\u8003\u8651\u5230\u4ee5\u524d\u7684\u5e38\u89c4\u6cbb\u7597\u5931\u8d25\uff0c\u533b\u751f\u56e0\u6b64\u5efa\u8bae\u5f00\u59cbSCD \u3002\u5979\u5f00\u59cb\u5b8c\u5168\u6392\u9664\u5c0f\u9ea6\uff0c\u5927\u8c46\uff0c\u5927\u9ea6\uff0c\u7389\u7c73\u548c\u6709\u9650\u7684\u5927\u7c73\u3002\u9664\u65e5\u5e38\u9178\u5976\u5916\uff0c\u4e0d\u5305\u62ec\u5176\u4ed6\u4e73\u5236\u54c1\u3002\u7cd6\u53ea\u9650\u4e8e\u8702\u871c\u3002\u6ca1\u6709\u98df\u7528\u542b\u6dc0\u7c89\u7684\u852c\u83dc\uff0c\u5e76\u4e14\u6d88\u9664\u4e86\u9a6c\u94c3\u85af\u3002\u5979\u4e3b\u8981\u5403\u9c7c\uff0c\u7626\u8089\uff0c\u67d0\u4e9b\u6c34\u679c\u548c\u53d7\u9650\u5236\u7684\u975e\u6dc0\u7c89\u7c7b\u852c\u83dc\u3002<\/p>\n \u5728\u4e25\u683c\u9650\u5236\u996e\u98df\u7684\u60c5\u51b5\u4e0b\uff0c\u57283\u52306\u4e2a\u6708\u5185\uff0c\u60a3\u8005\u5f00\u59cb\u6ce8\u610f\u5230\u75c5\u60c5\u6539\u5584\uff0c\u9891\u7387\u964d\u4f4e\uff0c\u5927\u4fbf\u66f4\u7262\u56fa\uff0c\u5927\u4fbf\u4e2d\u6ca1\u6709\u8840\u6db2\uff0c\u8179\u75db\u5f97\u5230\u7f13\u89e3\u3002\u57286\u4e2a\u6708\u5185\uff0c\u5979\u5f97\u4ee5\u6062\u590d\u6b63\u5e38\u7684\u5de5\u4f5c\u548c\u804c\u4e1a\u751f\u6daf\u3002\u865a\u5f31\u548c\u75b2\u52b3\u6d88\u5931\uff0c\u4f53\u91cd\u4fdd\u6301\u7a33\u5b9a\uff0c\u6ca1\u6709\u4efb\u4f55\u6062\u590d\u3002\u53d1\u73b0\u8d2b\u8840\u5df2\u6d88\u9664\uff0c\u8840\u7ea2\u86cb\u767d\u5728\u6b63\u5e38\u8303\u56f4\u5185\u3002\u7531\u4e8e\u6062\u590d\u826f\u597d\uff0c\u5979\u7ee7\u7eed\u4e25\u683c\u9075\u5b88\u996e\u98df\u4e60\u60ef\uff0c\u5e76\u5728\u63a5\u4e0b\u6765\u768418\u4e2a\u6708\u4e2d\u6d88\u9664\u4e86\u6240\u6709\u75c7\u72b6\u3002<\/p>\n \u57282012\u5e7412\u6708\u5f00\u59cb\u996e\u98df\u540e\u7684\u4e24\u5e74\u5185\u8fdb\u884c\u4e86\u968f\u540e\u7684\u7ed3\u80a0\u955c\u68c0\u67e5\uff0c\u5185\u7aa5\u955c\u68c0\u67e5\u7ed3\u679c\u663e\u793a\u660e\u663e\u6ca1\u6709\u4efb\u4f55\u708e\u75c7\uff08\u56fe2\uff09\u3002\u540c\u65f6\u83b7\u5f97\u7684\u6d3b\u68c0\u8bc1\u5b9e\u4e86UC\u7684\u5b8c\u5168\u7f13\u89e3\uff0c\u6ca1\u6709\u708e\u75c7\u6d3b\u52a8\u3002\u4ece\u90a3\u65f6\u8d77\uff0c\u5979\u6ce8\u610f\u5230\u610f\u5916\u98df\u7528\u5c0f\u9ea6\uff0c\u80e1\u6912\u548c\u5176\u4ed6\u672a\u7ecf\u6279\u51c6\u7684SCD\u98df\u7269\u4f1a\u5f15\u8d77\u6025\u6027\u53d1\u4f5c\uff0c\u800c\u8fc5\u901f\u6e05\u9664\u8fd9\u4e9b\u98df\u7269\u4f1a\u5728\u51e0\u5929\u5185\u6539\u5584\u75c7\u72b6\u3002\u81ea\u4ece\u996e\u98df\u5f00\u59cb\u4ee5\u6765\uff0c\u5979\u5c31\u4e0d\u9700\u8981\u4f4f\u9662\u6216\u63a5\u53d7UC\u7684\u5176\u4ed6\u6cbb\u7597\uff0c\u5e76\u4e14IBD\u57fa\u672c\u4e0a\u53ef\u4ee5\u7f13\u89e3\u3002<\/p>\n \u56de\u80a0\u672b\u7aef\uff08a<\/strong>\uff0cb<\/strong>\uff09\u548c\u76f2\u80a0\uff08c<\/strong>\uff09\u8868\u73b0\u51fa\u6b63\u5e38\u7684\u7ed3\u80a0\u7c98\u819c\uff0cSCD\u4e24\u5e74\u540e\u672a\u53d1\u708e\uff082012\u5e7412\u6708\uff09\u3002\u5b8c\u5168\u7684\u7ed3\u80a0\u955c\u68c0\u67e5\u8bc1\u5b9e\u4e86\u7ed3\u80a0\u6240\u6709\u8282\u6bb5\u7684\u5206\u8fa8\u7387<\/p>\n UC is known to have a peak in the age groups of 15\u201330 and 60\u201380 years\u00a0. In both children and adults, there are numerous diets and complementary therapies that have been used. However, at this time, there is little consensus among the complementary therapies. While gluten-free diets have been used for IBD in adults, the SCD has been found to be successful in a small retrospective study of 7 children\u00a0. Our case demonstrated unprecedented healing of recalcitrant and remitting UC, following institution of the SCD, in an adult.<\/p>\n This case study demonstrates the easy tolerability and lack of significant side effects of the SCD. Confirmation of healing with endoscopy and microscopy validates the clinical improvement experienced by this patient. The diet requirements were relatively simple to incorporate though highly restrictive and are similar to those undertaken\u00a0with celiac disease but included a prominent component of fermented dairy. A major strength of this case study is the ease of translation into clinical practice by busy clinicians, without the need for additional resources.<\/p>\n One of the limitations of this case study was the absence of definitive serological testing for celiac disease prior to the institution of the diet to determine occult gluten sensitivity. A further limitation of the dietary intervention are the restricted choices available outside of the home and the difficulty with absolute long-term adherence.<\/p>\n However, similar to patients with celiac disease, the food choices for patients on restricted diets has been steadily increasing in the United States, with gluten-free options having had a 63%percnt; increase in sales from 2012 to 2014. We anticipate that with greater promulgation of elimination diets, it will be more conducive to adhere outside of the home environment.<\/p>\n We would recommend that physicians and dieticians who are involved with gastrointestinal diseases look into alternative therapies, not only for patients with celiac disease but potentially also for those with IBD and UC. Further testing for specific food allergens and gut microbiome dysfunction could be helpful. Our suggestion is that future studies incorporate genetic markers and serological testing prior to making the changes.<\/p>\n The SCD has been used anecdotally for UC; however, the evidence of its effectiveness has not been conclusive. We report complete healing of UC in a patient who had failed conventional therapies within a 2-year period. The use of the SCD for UC in patients who are able to make sustainable dietary changes should be considered more often.<\/p>\n \u4f17\u6240\u5468\u77e5\uff0cUC\u572815-30\u5c81\u548c60-80\u5c81\u8fd9\u4e24\u4e2a\u5e74\u9f84\u6bb5\u6709\u53cc\u5cf0\u5cf0\u503c[4]\u3002\u65e0\u8bba\u662f\u513f\u7ae5\u8fd8\u662f\u6210\u4eba\uff0c\u90fd\u6709\u5927\u91cf\u7684\u996e\u98df\u548c\u8f85\u52a9\u7597\u6cd5\u3002\u7136\u800c\uff0c\u5728\u8fd9\u4e2a\u65f6\u5019\uff0c\u5728\u4e92\u8865\u7597\u6cd5\u4e2d\u51e0\u4e4e\u6ca1\u6709\u5171\u8bc6\u3002\u5c3d\u7ba1\u65e0\u9eb8\u8d28\u996e\u98df\uff08GFCF\uff09\u5df2\u7528\u4e8e\u6210\u4ebaIBD\uff0c\u4f46SCD\u5728\u4e00\u9879\u5bf97\u540d\u513f\u7ae5\u7684\u5c0f\u578b\u56de\u987e\u6027\u7814\u7a76\u4e2d\u88ab\u53d1\u73b0\u662f\u6210\u529f\u7684[5]\u3002\u6211\u4eec\u7684\u75c5\u4f8b\u663e\u793a\uff0c\u7ee7SCD\u6cbb\u7597\u540e\uff0c\u4e00\u540d\u6210\u4eba\u51fa\u73b0\u4e86\u524d\u6240\u672a\u6709\u7684\u987d\u56fa\u6027\u548c\u7f13\u89e3\u6027UC\u7684\u6108\u5408\u3002\u3002<\/p>\n \u8be5\u6848\u4f8b\u7814\u7a76\u8bc1\u660e\u4e86SCD\u6613\u4e8e\u8010\u53d7\u5e76\u4e14\u6ca1\u6709\u660e\u663e\u7684\u526f\u4f5c\u7528\u3002\u901a\u8fc7\u5185\u7aa5\u955c\u68c0\u67e5\u548c\u663e\u5fae\u955c\u68c0\u67e5\u786e\u8ba4\u6cbb\u6108\uff0c\u8bc1\u5b9e\u4e86\u60a3\u8005\u7684\u4e34\u5e8a\u6539\u5584\u3002\u996e\u98df\u8981\u6c42\u867d\u7136\u76f8\u5bf9\u4e25\u683c\uff0c\u4f46\u76f8\u5bf9\u6765\u8bf4\u5374\u6bd4\u8f83\u5bb9\u6613\u6444\u5165\uff0c\u4e0e\u4e73\u7cdc\u6cfb\u76f8\u4f3c\uff0c\u4f46\u5176\u4e2d\u5305\u62ec\u53d1\u9175\u4e73\uff08scd\u9178\u5976\uff09\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002\u8be5\u6848\u4f8b\u7814\u7a76\u7684\u4e3b\u8981\u4f18\u52bf\u5728\u4e8e\uff0c\u7e41\u5fd9\u7684\u4e34\u5e8a\u533b\u751f\u53ef\u4ee5\u8f7b\u677e\u5730\u5c06\u5176\u8f6c\u6362\u4e3a\u4e34\u5e8a\u5b9e\u8df5\uff0c\u800c\u65e0\u9700\u989d\u5916\u7684\u8d44\u6e90\u3002<\/p>\n \u8be5\u6848\u4f8b\u7814\u7a76\u7684\u5c40\u9650\u6027\u4e4b\u4e00\u662f\uff0c\u5728\u786e\u5b9a\u996e\u98df\u7684\u6f5c\u4f0f\u6027\u9762\u7b4b\u654f\u611f\u6027\u4e4b\u524d\uff0c\u6ca1\u6709\u5bf9\u4e73\u7cdc\u6cfb\u8fdb\u884c\u660e\u786e\u7684\u8840\u6e05\u5b66\u68c0\u6d4b\u3002\u996e\u98df\u5e72\u9884\u7684\u53e6\u4e00\u4e2a\u5c40\u9650\u6027\u662f\u5728\u5bb6\u5ead\u5916\u7684\u9009\u62e9\u53d7\u9650\uff0c\u4ee5\u53ca\u957f\u671f\u575a\u6301\u7684\u56f0\u96be\u3002<\/p>\n \u7136\u800c\uff0c\u4e0e\u4e73\u7cdc\u6cfb\u60a3\u8005\u76f8\u4f3c\uff0c\u5728\u7f8e\u56fd\uff0c\u9650\u5236\u996e\u98df\u60a3\u8005\u7684\u98df\u7269\u9009\u62e9\u4e00\u76f4\u5728\u7a33\u6b65\u589e\u52a0\uff0c\u65e0\u9eb8\u8d28\u98df\u54c1\u7684\u6bd4\u4f8b\u4e3a63%\uff1b2012\u5e74\u81f32014\u5e74\u7684\u9500\u552e\u989d\u6709\u6240\u589e\u52a0[6]\u3002\u6211\u4eec\u9884\u8ba1\uff0c\u968f\u7740\u9650\u5236\u996e\u98df\u7684\u66f4\u5e7f\u6cdb\u7684\u9881\u5e03\uff0c\u5b83\u5c06\u66f4\u6709\u5229\u4e8e\u575a\u6301\u5728\u5bb6\u5ead\u4ee5\u5916\u7684\u73af\u5883\u3002<\/p>\n \u6211\u4eec\u5efa\u8bae\u4e0e\u80c3\u80a0\u9053\u75be\u75c5\u6709\u5173\u7684\u533b\u751f\u548c\u8425\u517b\u5e08\u4e0d\u4ec5\u8981\u5bf9\u8179\u8154\u75be\u75c5\u60a3\u8005\uff0c\u800c\u4e14\u8fd8\u5e94\u5bf9IBD\u548cUC\u60a3\u8005\u8fdb\u884c\u7814\u7a76\u3002\u8fdb\u4e00\u6b65\u6d4b\u8bd5\u7279\u5b9a\u7684\u98df\u7269\u8fc7\u654f\u539f\u548c\u80a0\u9053\u5fae\u751f\u7269\u7ec4\u529f\u80fd\u969c\u788d\u53ef\u80fd\u4f1a\u6709\u6240\u5e2e\u52a9\u3002\u6211\u4eec\u7684\u5efa\u8bae\u662f\uff0c\u5728\u8fdb\u884c\u66f4\u6539\u4e4b\u524d\uff0c\u672a\u6765\u7684\u7814\u7a76\u5e94\u7ed3\u5408\u9057\u4f20\u6807\u8bb0\u548c\u8840\u6e05\u5b66\u68c0\u6d4b\u3002<\/p>\n SCD\u5df2\u88abUC\u5e7f\u6cdb\u4f7f\u7528\uff1b\u4f46\u662f\uff0c\u5176\u6709\u6548\u6027\u7684\u8bc1\u636e\u5c1a\u65e0\u5b9a\u8bba\u3002\u6211\u4eec\u62a5\u544a\u4e86\u57282\u5e74\u5185\u5e38\u89c4\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\u4e2dUC\u7684\u5b8c\u5168\u6cbb\u6108\u3002\u5e94\u8be5\u66f4\u575a\u5b9a\u5730\u8003\u8651\u5c06SCD\u7528\u4e8e\u80fd\u591f\u6301\u7eed\u6539\u53d8\u996e\u98df\u7684UC\u60a3\u8005\u3002<\/p>\n \u8be5\u75c5\u4f8b\u62a5\u544a\u4ee5\u524d\u66fe\u57282015\u5e74\u5b9e\u9a8c\u751f\u7269\u5b66\u4f1a\u8bae\u4e0a\u4f5c\u4e3a\u6d77\u62a5\u5c55\u793a\u3002\u8be5\u75c5\u4f8b\u62a5\u544a\u7684\u6458\u8981\u5148\u524d\u5df2\u5728\u5176\u76f8\u5e94\u7684\u671f\u520a[FASEB J 2015; 29\uff1a912.7]\u4e0a\u76842015\u5e74\u5b9e\u9a8c\u751f\u7269\u5b66\u5927\u4f1a\u4e0a\u53d1\u8868\u3002<\/p>\n 1.\u00a0Gasche C\uff0cScholmeric J\uff0cBrynskov J\u7b49\u3002\u514b\u7f57\u6069\u6c0f\u75c5\u7684\u7b80\u5355\u5206\u7c7b\uff1a\u4e16\u754c\u80c3\u80a0\u75c5\u5b66\u5927\u4f1a\u5de5\u4f5c\u7ec4\u7684\u62a5\u544a\uff0c\u7ef4\u4e5f\u7eb3\uff0c1998\u5e74\u3002InflammBowel Dis\u30022000;\u00a06\uff1a8\u3002[\u00a0PubMed\u00a0]\u00a0[\u00a0Google Scholar\u00a0]\n 2.\u00a0Peppercorn MA\uff1a\u708e\u6027\u80a0\u75c5\u7684\u5b9a\u4e49\uff0c\u6d41\u884c\u75c5\u5b66\u548c\u5371\u9669\u56e0\u7d20\uff1b\u5728Grover S\uff08ed\uff09\u4e2d\uff1aUptoDate\u30022015\u5e74\u3002http:\/\/www.uptodate.com\/contents\/definition-epidemiology-and-risk-factors-in-immuno-bowel-disease\u3002<\/p>\n 3.\u00a0Gottschall E.\u00a0\u6253\u7834\u6076\u6027\u5faa\u73af\u3002\u67ef\u514b\u987f\uff1a\u67ef\u514b\u987f\u51fa\u7248\u793e\uff1b1994.\u00a0[\u00a0Google Scholar\u00a0]\n 4.\u00a0Harrison T\uff0cLongo D.\u00a0Harrison\u7684\u533b\u5b66\u624b\u518c\u3002\u7ebd\u7ea6\uff1a\u9ea6\u683c\u52b3-\u5e0c\u5c14\u533b\u7597\u516c\u53f8\uff1b2013.\u00a0[\u00a0Google Scholar\u00a0]\n 5.\u00a0Suskind DL\uff0cWahbeh G\uff0cGregory N\uff0cVendettuoli H\uff0cChristieD\u3002\u5c0f\u513f\u514b\u7f57\u6069\u75c5\u7684\u8425\u517b\u7597\u6cd5\uff1a\u7279\u5b9a\u7684\u78b3\u6c34\u5316\u5408\u7269\u996e\u98df\u3002J Pediatr\u80c3\u80a0\u98df\u54c1\u30022014;\u00a058\uff1a87-91\u3002[\u00a0PubMed\u00a0]\u00a0[\u00a0Google Scholar\u00a0]\n 6.\u00a0\u65e0\u9eb8\u8d28\u98df\u54c1\u6fc0\u589e63\uff05\uff1b\u5728\u8fc7\u53bb\u4e24\u5e74\u4e2d\u3002\u82f1\u654f\u7279\u96c6\u56e2\u6709\u9650\u516c\u53f8\uff1b2014\u5e74\u00a0\u3002http:\/\/www.mintel.com\/press-centre\/food-and-drink\/gluten-free-foods-surge-63-percent\u3002[\u00a0Google Scholar\u00a0]\n","protected":false},"excerpt":{"rendered":" \u6458\u8981 A 73-year-old female of Asian origin was diagnosed w …<\/p>\n","protected":false},"author":1,"featured_media":1242,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[31],"tags":[],"_links":{"self":[{"href":"http:\/\/www.scd520.com\/index.php?rest_route=\/wp\/v2\/posts\/407"}],"collection":[{"href":"http:\/\/www.scd520.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.scd520.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.scd520.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.scd520.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=407"}],"version-history":[{"count":1,"href":"http:\/\/www.scd520.com\/index.php?rest_route=\/wp\/v2\/posts\/407\/revisions"}],"predecessor-version":[{"id":1243,"href":"http:\/\/www.scd520.com\/index.php?rest_route=\/wp\/v2\/posts\/407\/revisions\/1243"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.scd520.com\/index.php?rest_route=\/wp\/v2\/media\/1242"}],"wp:attachment":[{"href":"http:\/\/www.scd520.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.scd520.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=407"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.scd520.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"http:\/\/hdygyy.com.cn\/wp-content\/uploads\/2020\/10\/640-4-1.png\")
<\/p>\n\u8ba8\u8bba\u533a<\/h2>\n
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